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Living with Cutaneous leukocytoclastic angiitis

An allergic-type reaction to a drug, infection, or foreign substance that inflames small blood vessels in the skin.

Understanding Cutaneous leukocytoclastic angiitis

Cutaneous leukocytoclastic angiitis (cutaneous small vessel vasculitis) is an extreme reaction to a drug, infection, or foreign substance that inflames and damages blood vessels in the skin.

Signs can include purple spots and patches, skin lesions on the legs, buttocks, or trunk, blisters, hives, and open sores with dead tissue. It is caused by an allergic reaction to a drug or other foreign substance. It usually goes away over time, but some people have repeated episodes. It can occur at any age.

Signs & symptoms

Symptoms vary from person to person. GARD lists these among the most common:

  • Purple spots on the skin (purpura)
  • Skin rash and redness
  • Hives
  • Fever
  • Joint pain and muscle aches
  • Open sores with dead tissue

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Specialists who may be involved include autoimmune and inflammatory disease specialists.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

  4. Connect with expert centers

    Vasculitis Foundation may keep lists of experts for this condition.

Care & treatment

Care team
autoimmune and inflammatory disease specialists (rheumatologists)
Expert care
Expert lists: Vasculitis Foundation
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with Vasculitis Foundation
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
What drug or infection might be triggering this?
How can I avoid a trigger in the future?
What treatments can help the skin heal?

Quick facts

Symptoms usually startany time in life

It is caused by an allergic reaction to a drug or other foreign substance, or by infection.

Also known as: cutaneous hypersensitivity vasculitis; cutaneous leukocytoclastic vasculitis; cutaneous small vessel vasculitis; cutaneous small-vessel vasculitis; hypersensitivity angiitis

Patient organizations

Source: NIH GARD · Cutaneous leukocytoclastic angiitisGARD ID 7851 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Cutaneous leukocytoclastic angiitis.

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