Living with Curry-Hall syndrome
A genetic condition (Weyers acrofacial dysostosis) that affects the teeth, nails, and bones, often with short height and extra fingers.
Understanding Curry-Hall syndrome
Dental differences can include small, peg-shaped teeth, fewer teeth than usual, and a single front tooth instead of two. The lower jaw may have an unusual shape. Fingernails and toenails are small or malformed. Most people are relatively short and may have extra fingers or toes. It overlaps with a more severe condition, Ellis-van Creveld syndrome, which is caused by changes in the same genes. It is present from birth.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Small, cone-shaped teeth
- Fewer teeth than usual
- Small or malformed nails
- Extra little finger (polydactyly)
- Mild short stature
- Single upper front tooth
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include bone and joint specialists, genetic specialists and skin, hair, and nail specialists.
- 3Consider genetic testing
Changes in EVC2 are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
- 4Connect with expert centers
National Foundation for Ectodermal Dysplasias may keep lists of experts for this condition.
Care & treatment
- Care team
- Bone and joint specialists (orthopedists or orthopedic surgeons); Genetic specialists (geneticists); Skin, hair, and nail specialists (dermatologists)
- Expert care
- Expert lists: National Foundation for Ectodermal Dysplasias
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with National Foundation for Ectodermal Dysplasias and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
It is caused by changes in the EVC2 gene. It is autosomal dominant, meaning one changed copy of the gene can be enough to cause it.
Also known as: acrofacial dysostosis weyers type; acrofacial dysostosis, weyers type; wad; weyers acrodental dysostosis; weyers acrofacial dysostosis
Patient organizations
- National Foundation for Ectodermal DysplasiasEctodermal dysplasias · United States
- Children's Skin Disease FoundationSkin diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Curry-Hall syndrome.
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