Living with Congenital factor VII deficiency
A rare bleeding disorder with nosebleeds, easy bruising and heavy bleeding, which can range from very mild to severe.
Understanding Congenital factor VII deficiency
Severe cases may show up in infancy, and very mild cases may never cause bleeding problems. It can cause nosebleeds, easy bruising, bleeding gums, long bleeding after injury or surgery, and heavy periods. Some people have bleeding in joints or blood in the urine. Very severe cases can cause bleeding inside the skull or digestive tract.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Nosebleeds
- Easy bruising
- Bleeding gums
- Long bleeding after surgery or injury
- Heavy periods
- Bleeding into joints
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include blood and bone marrow specialists and genetic specialists.
- 3Consider genetic testing
Changes in F7 are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
- 4Connect with expert centers
Hemophilia Federation of America may keep lists of experts for this condition.
Care & treatment
- Care team
- Blood and bone marrow specialists (hematologists); Genetic specialists (geneticists)
- Expert care
- Expert lists: Hemophilia Federation of America
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Hemophilia Federation of America and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
It is caused by changes in the F7 gene. GARD lists autosomal recessive inheritance, and also autosomal dominant.
Also known as: congenital proconvertin deficiency; hereditary factor vii deficiency disease; hereditary factor vii deficiency syndrome; hereditary hypoproconvertinemia
Patient organizations
- Hemophilia Federation of AmericaCongenital factor VII deficiency · United States
- National Bleeding Disorders FoundationCongenital factor VII deficiency · United States
You are more than your diagnosis
Perspectives from people navigating life with Congenital factor VII deficiency.
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