Living with Complement component 2 deficiency
An inherited immune condition that raises the chance of repeated bacterial infections and autoimmune diseases such as lupus.
Understanding Complement component 2 deficiency
People have a higher risk of repeated bacterial infections in the lungs, around the brain and spinal cord, and in the blood. These are most common in infancy and childhood and become less frequent later. There is also a higher risk of autoimmune disorders such as lupus (SLE) or vasculitis. Severity varies widely, and some people have no health problems.
Signs & symptoms
GARD doesn't list a symptom list for this condition. The summary describes these:
- Repeated lung infections (pneumonia)
- Meningitis (infection around the brain and spinal cord)
- Blood infections (sepsis)
- Lupus (SLE) in 10 to 20 percent of people
- Vasculitis (inflamed blood vessels)
- Some people have no symptoms
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Your doctor may refer you to a specialist who knows rare conditions.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
- 4Connect with expert centers
Autoimmune Association and Immune Deficiency Foundation may keep lists of experts for this condition.
Care & treatment
- Care team
- A doctor familiar with rare conditions, plus specialists as needed
- Expert care
- Expert lists: Autoimmune Association, Immune Deficiency Foundation
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Autoimmune Association and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
GARD doesn't name a gene here. It is inherited in an autosomal recessive pattern, so a child inherits a changed copy of the gene from each parent.
Also known as: c2 complement deficiency; c2 deficiency; c2d; complement 2 deficiency; complement component c2 deficiency; complement deficiency caused by mutation in c2
Patient organizations
- Autoimmune AssociationComplement component 2 deficiency · United States
- Immune Deficiency FoundationComplement component 2 deficiency · United States
You are more than your diagnosis
Perspectives from people navigating life with Complement component 2 deficiency.
Explore research for Complement component 2 deficiency
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- Eligibility is confirmed by the study team
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