Living with Complement 3 glomerulopathy
A kidney condition where C3 protein collects in the kidney's filters, which can cause blood in the urine and high blood pressure.
Understanding Complement 3 glomerulopathy
It is a form of glomerulonephritis, which means inflamed kidney filters. A kidney biopsy shows mostly C3 staining. It is further classified as C3 glomerulonephritis (C3GN) or dense deposit disease (DDD). It can start at any time in life.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Blood in the urine
- Chronic kidney disease
- High blood pressure
- Low C3 level in the blood
- Kidney inflammation (membranoproliferative glomerulonephritis)
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include genetic specialists and kidney specialists.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
- 4Connect with expert centers
NephCure Kidney International may keep lists of experts for this condition.
Care & treatment
- Care team
- Genetic specialists (geneticists); Kidney specialists (nephrologists)
- Expert care
- Expert lists: NephCure Kidney International
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with NephCure Kidney International and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
GARD says changes in genes cause this condition, but doesn't list a specific gene or inheritance pattern.
Also known as: c3 glomerulopathy; c3g; non-ig-mediated membranoproliferative glomerulonephritis; non-ig-mediated mpgn; non-immunoglobulin-mediated membranoproliferative glomerulonephritis; non-immunoglobulin-mediated mpgn
Patient organizations
- NephCure Kidney InternationalComplement 3 glomerulopathy · United States
- HealthTree FoundationComplement 3 glomerulopathy · United States
- National Kidney FoundationKidney diseases · United States
- Renal Support NetworkKidney diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Complement 3 glomerulopathy.
Explore research for Complement 3 glomerulopathy
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- Recruiting studies from ClinicalTrials.gov
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