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Living with Chronic mucocutaneous candidiasis

A rare immune condition that causes long-lasting or repeated yeast infections of the skin, nails, and mouth lining.

Understanding Chronic mucocutaneous candidiasis

Chronic mucocutaneous candidiasis is a rare primary immunodeficiency with ongoing or repeated infections of the skin, nails, and mucous membranes.

The infections are mainly with a fungus called Candida albicans and can be hard to live with. GARD lists onset in infancy and childhood. Nail, lip, mouth, and skin changes are common.

Signs & symptoms

Symptoms vary from person to person. GARD lists these among the most common:

  • Repeated yeast infections of the skin and nails
  • Changes in fingernails and toenails
  • Changes in the mouth and lips
  • Skin changes
  • Immune system differences

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Specialists who may be involved include allergy and immune system specialists, genetic specialists and skin, hair, and nail specialists.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

  4. Connect with expert centers

    Immune Deficiency Foundation may keep lists of experts for this condition.

Care & treatment

Care team
Allergy and immune system specialists (allergists / immunologists); Genetic specialists (geneticists); Skin, hair, and nail specialists (dermatologists)
Expert care
Expert lists: Immune Deficiency Foundation
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with Jeffrey Modell Foundation and other patient organizations
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
Which immune tests or genetic tests could explain my infections?
Which specialists, such as immunologists, should be on my care team?
How can we watch for infections in other places in the body?

Quick facts

Symptoms usually startInfant and as a Child
InheritanceAutosomal Dominant, Autosomal Recessive

GARD doesn't name a gene. It is listed as inherited in either an autosomal dominant or autosomal recessive pattern.

GeneticSkin

Also known as: candf; chronic candidiasis of mucosa, skin and nails; chronic mucocutaneous candidiasis (disease); cmc; cmc - chronic mucocutaneous candidiasis; familial candidiasis

Patient organizations

Source: NIH GARD · Chronic mucocutaneous candidiasisGARD ID 1077 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Chronic mucocutaneous candidiasis.

Explore the Chronic mucocutaneous candidiasis blog

Explore research for Chronic mucocutaneous candidiasis

Explore actively recruiting Chronic mucocutaneous candidiasis studies with HealthSpark.

HealthSpark

Find actively recruiting studies for Chronic mucocutaneous candidiasis with HealthSpark. Share your city to explore research near you.

  • Recruiting studies from ClinicalTrials.gov
  • Share your city to look for research near you
  • Eligibility is confirmed by the study team

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Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.

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