Living with Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
An advanced phase of a blood cancer in which many immature white blood cells are made.
Understanding Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
CML involves a swap between chromosomes 9 and 22 called the Philadelphia chromosome. This makes an abnormal enzyme (tyrosine kinase) that causes abnormal white blood cell production. In the blast phase, 20% or more of cells in blood or bone marrow are blasts, and the disease behaves like acute leukemia.
Signs & symptoms
Symptoms vary from person to person. GARD lists these as symptoms:
- Fever
- Night sweats
- Bone pain
- Weight loss
- Tiredness
- Enlarged spleen
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Your doctor may refer you to a specialist who knows rare conditions.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
Care & treatment
- Care team
- A doctor familiar with rare conditions, plus specialists as needed
- Expert care
- Ask about multidisciplinary care centers for rare conditions
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with rare disease patient organizations for support
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
CML comes from an abnormal fusion of chromosomes 9 and 22, called the Philadelphia chromosome, which makes an abnormal enzyme (tyrosine kinase).
Also known as: blast crisis; blast crisis stage of chronic myeloid leukemia; blast phase chronic granulocytic leukaemia; blast phase chronic granulocytic leukemia; blast phase chronic myelocytic leukaemia; blast phase chronic myelocytic leukemia
Patient organizations
Rare-disease groups that can help
- Global GenesRare Diseases · United States
- National Organization for Rare DisordersRare Diseases · United States
- Genetic AllianceRare Diseases · United States
- RARE FoundationRare Diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Blast phase chronic myelogenous leukemia, BCR-ABL1 positive.
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