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Living with Baroreflex failure

A rare condition in which blood pressure swings between very high and low, with headaches and sweating.

Understanding Baroreflex failure

Baroreflex failure is a rare disorder that causes swings in blood pressure, with episodes of very high blood pressure and a fast heart rate.

High blood pressure and a fast heart rate come in response to stress, exercise, and pain. During rest, blood pressure can be low with a normal or slow heart rate. It can start at any time in life. In many cases the cause is not known.

Signs & symptoms

GARD doesn't list a symptom list. The summary describes these features:

  • Headache
  • Sweating
  • Episodes of very high blood pressure
  • Low blood pressure during rest
  • Heart rate that does not respond to medicines

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Specialists who may be involved include brain and nervous system specialists.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

Care & treatment

Care team
Brain and nervous system specialists (neurologists)
Expert care
Ask about multidisciplinary care centers for rare conditions
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with Dysautonomia Support Network
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
Which tests can confirm baroreflex failure?
Which specialist should manage my blood pressure swings?
Which triggers, such as stress or pain, should I watch for?

Quick facts

Symptoms usually startany time in life

In many cases the cause of baroreflex failure is not known.

Neurological

Also known as: baroreflex failure syndrome

Patient organizations

Source: NIH GARD · Baroreflex failureGARD ID 10664 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Baroreflex failure.

Explore the Baroreflex failure blog

Explore research for Baroreflex failure

Explore actively recruiting Baroreflex failure studies with HealthSpark.

HealthSpark

Find actively recruiting studies for Baroreflex failure with HealthSpark. Share your city to explore research near you.

  • Recruiting studies from ClinicalTrials.gov
  • Share your city to look for research near you
  • Eligibility is confirmed by the study team

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Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.

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