Living with Autosomal recessive spinocerebellar ataxia 10
A rare inherited condition with slowly worsening balance and coordination problems that starts in adulthood.
Understanding Autosomal recessive spinocerebellar ataxia 10
It affects walking, arm and leg coordination, speech, and eye movements. Reflexes are increased, and thinking can slowly decline. Other features can include leg muscle wasting and twitching, high-arched feet, seizures, retina changes, and cataracts. Brain scans show marked shrinking of the cerebellum.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Slowly worsening balance and coordination problems
- Unclear speech (dysarthria)
- Shaky eye movements (downbeat nystagmus)
- Shrinking of the cerebellum
- Brisk reflexes
- Seizures
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include brain and nervous system specialists and genetic specialists.
- 3Consider genetic testing
Changes in ANO10 are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
- 4Connect with expert centers
National Ataxia Foundation may keep lists of experts for this condition.
Care & treatment
- Care team
- Brain and nervous system specialists (neurologists); Genetic specialists (geneticists)
- Expert care
- Expert lists: National Ataxia Foundation
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with National Ataxia Foundation
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
It is caused by changes in the ANO10 gene. It is autosomal recessive, so a child inherits a changed copy of the gene from each parent.
Also known as: adult-onset autosomal recessive cerebellar ataxia; ano10 autosomal recessive cerebellar ataxia; autosomal recessive cerebellar ataxia caused by mutation in ano10; autosomal recessive spinocerebellar ataxia type 10; scar10; scar10 - autosomal recessive spinocerebellar ataxia type 10
Patient organizations
- National Ataxia FoundationAtaxia · United States
Broader rare-disease groups
- Global GenesRare Diseases · United States
- National Organization for Rare DisordersRare Diseases · United States
- Genetic AllianceRare Diseases · United States
- RARE FoundationRare Diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Autosomal recessive spinocerebellar ataxia 10.
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