Living with Anterior segment dysgenesis 3
A rare eye condition present from birth with dark, smooth-looking irises and early-onset glaucoma.
Understanding Anterior segment dysgenesis 3
The differences eventually lead to glaucoma (high pressure in the eye) at an early age. The irises are unusually dark and lack their usual pattern, giving them a smooth look. Brown irises look dark chocolate and blue irises look dark slate gray.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Pupil that is off-center (ectopia pupillae)
- Underdeveloped iris tissue (iris stroma)
- A ridge on the cornea (posterior embryotoxon)
- Unusually dark irises with a smooth look
- Early-onset glaucoma
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Your doctor may refer you to a specialist who knows rare conditions.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
Care & treatment
- Care team
- A doctor familiar with rare conditions, plus specialists as needed
- Expert care
- Ask about multidisciplinary care centers for rare conditions
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with BrightFocus Foundation
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
GARD says changes in the FOXC1 gene cause this condition. It is autosomal dominant, meaning one changed copy of the gene can be enough to cause it.
Also known as: anterior segment dysgenesis 3, multiple subtypes; asgd3; foxc1 iridogoniodysgenesis; glaucoma iridogoniodysplasia, familial; igda; igda syndrome
Patient organizations
- BrightFocus FoundationAnterior segment dysgenesis 3 · United States
You are more than your diagnosis
Perspectives from people navigating life with Anterior segment dysgenesis 3.
Explore research for Anterior segment dysgenesis 3
Explore actively recruiting Anterior segment dysgenesis 3 studies with HealthSpark.
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- Recruiting studies from ClinicalTrials.gov
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- Eligibility is confirmed by the study team
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Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.
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