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Living with Acute promyelocytic leukemia

A form of acute myeloid leukemia in which immature white blood cells build up in the bone marrow, leading to bleeding and bruising.

Understanding Acute promyelocytic leukemia

Acute promyelocytic leukemia is a form of acute myeloid leukemia, a cancer of the blood-forming tissue (bone marrow).

Immature white blood cells called promyelocytes build up in the bone marrow. This crowds out normal white and red blood cells and platelets. It is most often diagnosed around age 40, but can be diagnosed at any age.

Signs & symptoms

Symptoms vary from person to person. GARD lists these among the most common:

  • Easy bruising and bleeding
  • Nosebleeds and bleeding gums
  • Tiredness (fatigue)
  • Fever
  • Frequent infections
  • Shortness of breath with activity

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Specialists who may be involved include blood and bone marrow specialists and cancer specialists.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

Care & treatment

Care team
Blood and bone marrow specialists (hematologists); Cancer specialists (oncologists)
Expert care
Ask about multidisciplinary care centers for rare conditions
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with American Cancer Society and other patient organizations
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
Why do bleeding and bruising happen with this leukemia?
Which signs of bleeding should I report right away?
Which specialists should be on my care team?

Quick facts

Symptoms usually starta variety of ages

GARD doesn't describe a cause for this condition yet.

Blood

Also known as: acute myeloblastic leukaemia 3; acute myeloblastic leukaemia type 3; acute myeloblastic leukemia 3; acute myeloblastic leukemia type 3; acute myeloid leukaemia m3; acute myeloid leukaemia with t(15

Patient organizations

Source: NIH GARD · Acute promyelocytic leukemiaGARD ID 538 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Acute promyelocytic leukemia.

Explore the Acute promyelocytic leukemia blog

Explore research for Acute promyelocytic leukemia

Explore actively recruiting Acute promyelocytic leukemia studies with HealthSpark.

HealthSpark

Find actively recruiting studies for Acute promyelocytic leukemia with HealthSpark. Share your city to explore research near you.

  • Recruiting studies from ClinicalTrials.gov
  • Share your city to look for research near you
  • Eligibility is confirmed by the study team

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Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.

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