Skip to content
knowrare
HealthSignal
Your condition community

Living with Acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2)

A subtype of acute myeloid leukemia with a specific chromosome change, causing fatigue, bruising, bleeding, and infections.

Get Signals Ask Anything

Understanding Acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2)

Acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2) is a subtype of acute myeloid leukemia with a recurring genetic change.

Immature blood cells called blasts grow in the bone marrow and blood, and rarely in other tissues. People typically have a high white blood cell count, anemia, and platelet counts that vary. GARD notes this subtype is reported to resist standard chemotherapy.

Signs & symptoms

Symptoms vary from person to person. GARD's summary says they may include:

  • Tiredness (fatigue)
  • Bleeding
  • Bruising
  • Infections that keep coming back
  • Bone pain
  • Swollen gums or enlarged spleen

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Specialists who may be involved include blood and bone marrow specialists and cancer specialists.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

Care & treatment

Care team
Blood and bone marrow specialists (hematologists); Cancer specialists (oncologists)
Expert care
Ask about multidisciplinary care centers for rare conditions
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with Blood Cancer United and other patient organizations
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
What does this chromosome change mean for my treatment options?
Why is this subtype reported to resist standard chemotherapy?
Which specialists should be on my care team?

Quick facts

GARD describes a recurring chromosome change, inv(3)(p21;q26.2) or t(3;3)(p21;q26.2), in this subtype. It doesn't describe a cause beyond that.

Blood

Also known as: acute myeloid leukemia with inv(3)(q21q26.2) or t(3; 3)(q21; q26.2); rpn1-evi1; acute myeloid leukemia with mecom rearrangement; aml with inv3(p21

Patient organizations

Source: NIH GARD · Acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2)GARD ID 12759 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2).

Explore the Acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2) blog
Broader resource

9 Things to Know After Diagnosis

Read article
Broader resource

The Invisible Job: What Caregiving for a Rare Disease Really Looks Like

Read article
Broader resource

Embrace the Ask: How to Seek The Support You Need

Read article
Your experience could help someone else.

Share your story with our editorial team.

Share your story You choose what to share.

Explore research for Acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2)

Explore actively recruiting Acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2) studies with HealthSpark.

HealthSpark

Find actively recruiting studies for Acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2) with HealthSpark. Share your city to explore research near you.

  • Recruiting studies from ClinicalTrials.gov
  • Share your city to look for research near you
  • Eligibility is confirmed by the study team

Powered by HealthSpark, our AI chat helper

I can help you find recruiting Acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2) studies. Enter a ZIP code, address or city below and I'll look within 50 miles.

Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.

Get Signals for Acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2)

Stay in the loop with community stories and updates from medical researchers.

HealthStoryfor Acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2)

Create a living journal that talks back

HealthStory evolves private journaling with a living AI journal that talks back and asks thoughtful questions, helping you capture your Acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2) experiences more deeply and prepare for better conversations with your doctors and care team.

Start your journal

Your journal is private. Sharing your story publicly is a separate choice, made with Share your story above.