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Living with Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)

A type of acute myeloid leukemia (also called acute myelomonocytic leukemia) that develops in the bone marrow and blood.

Understanding Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)

Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) is a cancer of the bone marrow and blood.

GARD describes it as acute myelomonocytic leukemia (AMML), one type of acute myeloid leukemia. These are blood cancers in which the number of white blood cells increases rapidly. GARD lists the onset as adulthood.

Signs & symptoms

Symptoms vary from person to person. GARD's summary says they often include:

  • Tiredness (fatigue) from low red blood cells (anemia)
  • Easy bruising or bleeding from low platelets (thrombocytopenia)

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Specialists who may be involved include blood and bone marrow specialists and cancer specialists.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

Care & treatment

Care team
Blood and bone marrow specialists (hematologists); Cancer specialists (oncologists)
Expert care
Ask about multidisciplinary care centers for rare conditions
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with Blood Cancer United and other patient organizations
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
What chromosome change was found in my leukemia cells?
How are tiredness and easy bruising being managed?
Which specialists should be on my care team?

Quick facts

Symptoms usually startAdult

GARD says the cause of AMML is currently unknown.

Blood

Also known as: acute myeloid leukemia with cbfb::myh11 fusion; acute myeloid leukemia with inv(16)(p13.1q22); acute myeloid leukemia with t(16; 16)(p13.1; q22); acute myelomonocytic leukemia - eosinophilic variant

Patient organizations

Source: NIH GARD · Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)GARD ID 536 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22).

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