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Living with Acute leukemia of ambiguous lineage

A rare blood cancer in which immature blood cells can't be clearly labeled as one type of blood cell.

Understanding Acute leukemia of ambiguous lineage

Acute leukemia of ambiguous lineage is a rare blood cancer that affects immature blood-forming cells called blasts.

The blast cells either don't have enough features to be called myeloid or lymphoid cells, or they have features of both. Doctors decide this by looking at the cells under a microscope and testing for specific cell markers. It can start at any time in life.

Signs & symptoms

GARD doesn't list specific symptoms for this condition yet.

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Specialists who may be involved include blood and bone marrow specialists and cancer specialists.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

Care & treatment

Care team
Blood and bone marrow specialists (hematologists); Cancer specialists (oncologists)
Expert care
Ask about multidisciplinary care centers for rare conditions
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with Blood Cancer United and other patient organizations
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
Which cell markers were found on my blast cells?
How does this affect the treatment options?
Which specialists should be on my care team?

Quick facts

Symptoms usually startany time in life

GARD doesn't describe a cause for this condition yet.

Blood

Also known as: acute leukaemia of indeterminate lineage; acute leukemia of indeterminate lineage; hybrid acute leukaemia; hybrid acute leukemia; mixed lineage acute leukaemia; mixed lineage acute leukemia

Patient organizations

Source: NIH GARD · Acute leukemia of ambiguous lineageGARD ID 8638 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Acute leukemia of ambiguous lineage.

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Explore research for Acute leukemia of ambiguous lineage

Explore actively recruiting Acute leukemia of ambiguous lineage studies with HealthSpark.

HealthSpark

Find actively recruiting studies for Acute leukemia of ambiguous lineage with HealthSpark. Share your city to explore research near you.

  • Recruiting studies from ClinicalTrials.gov
  • Share your city to look for research near you
  • Eligibility is confirmed by the study team

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Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.

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