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Living with Acute graft versus host disease

Tissue damage caused by the immune system after a donor transplant, most often in the skin, liver, and gut.

Understanding Acute graft versus host disease

Acute graft versus host disease is a syndrome of immune-driven tissue damage that may occur after an allogeneic (donor) transplant.

It usually affects the skin, liver, and digestive (GI) tract. It usually begins within 100 days of the transplant.

Signs & symptoms

GARD doesn't list specific symptoms for this condition yet.

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Specialists who may be involved include allergy and immune system specialists.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

  4. Connect with expert centers

    Aplastic Anemia and MDS International Foundation may keep lists of experts for this condition.

Care & treatment

Care team
Allergy and immune system specialists (allergists / immunologists)
Expert care
Expert lists: Aplastic Anemia and MDS International Foundation
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with Aplastic Anemia and MDS International Foundation
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
Which signs in my skin, liver, or gut should I report right away?
How will my team watch for this in the first 100 days?
Which specialists will manage this condition?

Quick facts

GARD describes it as tissue damage caused by the immune system that may occur after an allogeneic (donor) transplant. It doesn't list a gene cause.

Also known as: acute graft vs. host disease; acute graft-versus-host disease; fulminant graft versus host disease; graft versus host disease, acute; gvhd, acute

Patient organizations

Source: NIH GARD · Acute graft versus host diseaseGARD ID 6544 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Acute graft versus host disease.

Explore the Acute graft versus host disease blog

Explore research for Acute graft versus host disease

Explore actively recruiting Acute graft versus host disease studies with HealthSpark.

HealthSpark

Find actively recruiting studies for Acute graft versus host disease with HealthSpark. Share your city to explore research near you.

  • Recruiting studies from ClinicalTrials.gov
  • Share your city to look for research near you
  • Eligibility is confirmed by the study team

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Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.

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